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CJC-1295 without DAC, also known as Modified GRF 1-29, is a synthetic analogue of growth hormone-releasing hormone (GHRH). Unlike its DAC counterpart, it does not include a Drug Affinity Complex, so it clears the body quickly and produces a more defined, pulsatile release of growth hormone. Ipamorelin is a selective growth hormone secretagogue and ghrelin mimetic that stimulates GH release through a separate receptor pathway. When combined, these two peptides work synergistically: CJC-1295 w/o DAC amplifies the GH pulse signal, and Ipamorelin triggers release via a complementary mechanism, producing a stronger and more natural GH pulse than either compound alone. This stack is widely researched for its effects on body composition, recovery, and sleep quality.
The CJC-1295 w/o DAC and Ipamorelin combination is researched for its ability to produce clean, pulsatile GH release that closely mimics the body's natural secretion patterns. Studies suggest the stack supports lean muscle development, fat metabolism, and recovery from training. Because Ipamorelin is highly selective for GH release and does not significantly raise cortisol or prolactin, it is considered one of the cleaner secretagogue options available for research. The short half-life of CJC-1295 w/o DAC also means GH pulses are more controlled compared to long-acting analogues. Users in research contexts report improvements in sleep quality, body composition, and tissue recovery over the course of a protocol.
These ranges are general, research-use suggestions to help you prepare your peptides. This calculator and recommended doses are not medical advice. Start low, assess tolerance, and adjust cautiously.
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A synergistic GHRH and secretagogue stack researched for pulsatile GH release, body composition support, and recovery.
Amplifies natural GH pulses; supports lean mass and fat metabolism; cleaner secretagogue profile than long-acting analogues.
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One vial of CJC-1295 w/o DAC + Ipamorelin contains 5mg of CJC-1295 w/o DAC and 5mg of Ipamorelin to a combined 10mg. Substance strictly intended for laboratory research purposes only.
Side effects associated with this combination are generally mild relative to other GH-stimulating compounds. The most commonly reported include transient water retention, mild headaches, and tingling or flushing shortly after injection. Some users experience temporary lethargy or increased hunger, the latter being more associated with Ipamorelin's ghrelin-mimetic activity. As with any compound that elevates GH and IGF-1, there is a theoretical risk of promoting the growth of pre-existing abnormal cells, though this has not been conclusively demonstrated in research settings.
Research protocols for this combination typically use doses of 100–300 mcg of each peptide per injection, administered subcutaneously 2–3 times per day. Injections are most commonly timed in a fasted state, particularly before bed to align with the body's natural overnight GH pulse, and optionally upon waking or pre-workout. Because CJC-1295 w/o DAC has a short half-life of approximately 30 minutes, timing relative to meals matters more than with long-acting analogues. Protocols commonly run 8–12 weeks. Both peptides are typically combined in the same injection.
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