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5-Amino-1MQ is a selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue that depletes cellular NAD+ and shifts fat metabolism toward storage. By blocking NNMT, 5-Amino-1MQ preserves the nicotinamide pool available for NAD+ synthesis, restoring mitochondrial energy output and promoting fat oxidation. Preclinical studies in diet-induced obese mice demonstrated significant reductions in body weight, white adipose mass, adipocyte size, and plasma cholesterol without changes in food intake or observable adverse effects. It is not a true peptide but a quinolinium salt, often categorized alongside research peptides.
5-Amino-1MQ is a next-generation NNMT inhibitor studied for its effects on fat mass reduction, NAD+ restoration, and metabolic efficiency. By blocking NNMT, the compound preserves nicotinamide for the NAD+ salvage pathway, activating sirtuins (including SIRT1) and driving mitochondrial energy output rather than fat storage. In preclinical models, treated subjects showed reductions in white adipose mass and adipocyte size, improved insulin sensitivity, better glucose clearance, and lower plasma cholesterol. These changes occurred without alterations to food intake, distinguishing 5-Amino-1MQ from appetite-based compounds and pointing to a thermogenic, metabolic reprogramming mechanism. Research also supports potential applications in aged muscle regeneration, with NNMT inhibition shown to enhance muscle stem cell function and fiber size in older animal models.
These ranges are general, research-use suggestions to help you prepare your peptides. This calculator and recommended doses are not medical advice. Start low, assess tolerance, and adjust cautiously.
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A next-generation NNMT inhibitor studied for fat mass reduction and body composition research, frequently referenced in cutting phases for its ability to shift cellular metabolism toward increased fat oxidation without altering food intake.
Selective NNMT inhibition; Supports NAD+ restoration and fat oxidation; Research-backed metabolic reprogramming compound.
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5-Amino-1MQ is a selective NNMT inhibitor studied for its effects on fat metabolism, NAD+ preservation, and body composition. For lab research use only.
5-Amino-1MQ has demonstrated a favourable safety profile in preclinical studies, with no significant adverse effects observed at tested doses. Reported side effects in research contexts are generally mild and transient, including nausea or GI discomfort (particularly at the start of a protocol), headache, and occasional mild stimulatory effects. GI symptoms may be reduced by dosing alongside a light meal. It is not recommended for use during pregnancy or breastfeeding, or in subjects with uncontrolled cardiovascular conditions, liver or kidney impairment, or those on medications affecting NAD+ metabolism. Human safety data remain limited, and long-term effects are not established. For research use only.
5-Amino-1MQ (50mg vial) is administered via subcutaneous injection. Reconstitute with 4.0 mL bacteriostatic water to yield a 12.5 mg/mL solution. The standard research dose ranges from 2.5–5 mg once or twice daily. A single 50mg vial provides approximately 10–20 days of material at these doses. Store lyophilized at −20°C (−4°F); once reconstituted, refrigerate at 2–8°C (35.6–46.4°F) and use within 2–4 weeks. Common research protocols run 8–12 weeks on, followed by a 4–6 week washout. Rotate injection sites to avoid lipohypertrophy.
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